Evidence for the association of ‘soluble’ enzymes in vivo is extensive and compelling. These associations occur in all compartments of the cell of both prokaryotes and eukaryotes. Several factors present in vivo promote these associations among enzymes whose association in vitro is often too weak to detect. Several physiological advantages of the associated enzyme complexes can be identified, most (but not all) of which are the consequence of microcompartmentation of metabolites (substrate channeling). Substrate channeling of intermediates by either a ‘direct (...) transfer’ process or ‘proximity effects’ can occur. The latter mechanism does not require the special molecular features needed for the direct transfer mechanism and may, therefore, exist in more general situations in the cell. Criticisms of these views are discussed. We argue that these criticisms have been largely answered by experiment and theory in recent years. Studies on simple systems in vitro, nevertheless, contribute important insights concerning the more complex phenomena in vivo. (shrink)

Philosophical Investigations, EarlyView.

Rhees seems unaware that Simone Weil differed from him both in her conception of philosophy and of its relation to religion. She differed also in her view of the relation between religion and science. On her view, the aim of science is to find the laws which will allow us to apply deductive reasoning to nature. The necessities revealed had for her a religious significance. But this can be understood only given her view of the relation between God and the (...) world. On her view, the creation of the world did not involve an extension of God's power. It involved a withdrawal of his power, so that there could be an existence independent of himself. God does not interfere in the details of the world but sustains it through a network of necessities. For this reason, these necessities can serve as a sign of God. (shrink)

When scientists consider the interaction of science and value judgments, debates often occur. When public policy grows out of science, disagreements between scientists can become even more spirited. This paper examines the case of nutrition policy in the United States, which has been both at the interface between agriculture and medicine and the object of serious discord concerned with the strength and validity of the scientific evidence and the responsibility for action. The development of indirect intervention policies, designed to educate (...) and inform the public on diet and health, is traced as a practical demonstration of the effects of involvements of nutritional scientists of different disciplines and philosophic bents. Controversies centered mainly on the issues of diet and coronary heart disease and of diet and cancer in nutritional guidelines for Americans and the recommended dietary allowances. But the arguments turned on a complex web of values and interests as well as scientific questions. A remarkable turnaround by animal agriculture and its scientific support occurred, changing from a defensive, rightist stance to one that appears to recognize a moral responsibility to the public health. The convincing point was likely the changing market. Nutritional scientists, however, remained divided on the issue of whether a public health strategy keyed to public education should replace a strategy to identify persons of high risk and modify the risk by treatment. Our analysis suggests that the tension between libertarian and utilitarian social values of scientists is at least as important as disagreements relative to validity and strengths of the scientific evidence. (shrink)

Book reviewed in this article:F.H. Bradley, Collected Works Volumes 1–5.

Metaphysics -- Bacon -- Locke -- Kant -- Comte -- Logical positivism -- Russell -- Analysis -- Quine and science -- Wittgenstein.

In a symposium with Roger Trigg, Renford Bambrough remarks that in discussing the difference between reason and faith philosophers too often raise the issue in a misleading form.1 The form is that of the ‘treacherous singular’. In other words, they assume that there is a single difference between reason and faith, that a line may be drawn with faith entirely on one side and reason entirely on the other. Against this, Bambrough argues that there is no sharp difference between the (...) two, that they are related in many ways and that within the network of our discourse they come to different things at different points. Philosophers too often look only at one or two points, assume a radical divergence and produce a caricature alike of reason and of faith. A more extensive view will reveal no such radical incompatibility; rather it will enable us to see faith as a mode of reason. (shrink)

This title was first published in 2001: Tolstoy's view of art is discussed in most courses in aesthetics, particularly his main text What is Art? He believed that the importance of art lies not in its purely aesthetic qualities but in its connection with life, and that art becomes decadent where this connection is lost. This view has often been misconceived and its strength overlooked. This book presents a clear exposition of Tolstoy's What is Art?, highlighting the value and importance (...) of Tolstoy's views in relation to aesthetics. Mounce considers the problems which exercised Tolstoy and explains their fundamental importance in contemporary disputes. Having viewed these problems of aesthetics as they arise in a classic work, Howard Mounce affords readers fresh insights not simply into the problems of aesthetics themselves, but also into their contemporary treatment. Students and interested readers of aesthetics and philosophy, as well as those exploring the works of Tolstoy in literature, will find this book of particular interest and will discover that reading What is Art? with attention, affords something of the excitement found in removing the grime from an oil painting - gradually from underneath there appears an authentic masterpiece. (shrink)

Nocebo effects occur when an individual experiences undesirable physiological reactions caused by doxastic states that are not a treatment’s core or characteristic features.1 As Scott Gelfand2 points out, there are numerous studies that have shown that the disclosure of a treatment’s side effects to a patient increases the risk of the side effects. From an ethical point of view, nocebo effects caused by the disclosures of side effects present a challenging problem. On the one hand, clinicians’ duty to inform patients (...) of the consequences (including possible side effects) of their treatments is critical in ensuring that patients’ autonomy is respected. Patients cannot act autonomously if relevant information is withheld from them (without their consent, perhaps). On the other hand, clinicians also ought to minimize harm to patients. (shrink)